Immunogenic and antigenic epitopes of immunoglobulins--VII. The topographical distribution of Fc gamma epitopes and the relationship of an iso-allotypic specificity to the presence of histidine 435.
Mol Immunol
; 21(2): 137-43, 1984 Feb.
Article
en En
| MEDLINE
| ID: mdl-6200772
ABSTRACT
Epitopes recognised by a panel of 23 anti-Fc gamma monoclonal antibodies (McAbs) have been subdivided into three groups each having a distinct topographical distribution. One group of mutually inhibitory McAbs are reactive with epitopes expressed on the fy "surface" of the C gamma 2 domain. A second group recognises epitopes in the region of arginine 355 of the C gamma 3 domain whilst the third group recognises epitopes expressed in the inter C gamma 2/C gamma 3 domain region--as evidenced by inhibition of Staphylococcus aureus protein A binding. An antibody of the latter group reactive with IgG1, 2, 4 and IgG3m(15,16) proteins but not IgG3m(5) or IgG3m(21) proteins allows histidine 435 to be identified as a critical residue for expression of the epitope recognised by this antibody.
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Banco de datos:
MEDLINE
Asunto principal:
Fragmentos Fc de Inmunoglobulinas
/
Fragmentos de Inmunoglobulinas
/
Cadenas gamma de Inmunoglobulina
/
Cadenas Pesadas de Inmunoglobulina
/
Epítopos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Año:
1984
Tipo del documento:
Article