[Patterns of thrombocytopoiesis regulation]. / Zakonomernosti reguliatsii trombotsitopoéza.

ABSTRACT

Based on literature data, the main kinds of thrombocytopoiesis regulation are analyzed. It is shown that humoral factors regulate the intensity of proliferation of committed precursors and the mean sizes of mature megakaryocytes. The activity of these factors depends on the numbers of thrombocytes in blood and of megakaryocytes in bone marrow. The evidence presented in the review enables one to give a quantitative description of the relationship between the rate of thrombocytopoiesis and the content of thrombocytes in blood. The fact that the alteration of the time of megakaryocyte maturation does not depend on the duration and strength of the influences points to a non-specificity of this reaction. A scheme for the thrombopoiesis regulation is proposed which can serve as a basis for its mathematic description.