Chemotherapeutic study on Yoshida sarcoma ascites cells implanted into the glandular stomach of rats. Monotherapy with 5-fluorouracil, methyl-CCNU, mitomycin C, adriamycin, and cytosine arabinoside, and combination therapy with respective two-drug combinations.
J Cancer Res Clin Oncol
; 105(3): 250-7, 1983.
Article
en En
| MEDLINE
| ID: mdl-6406513
ABSTRACT
The chemotherapeutic activity of five cytostatic drugs was investigated experimentally in monotherapy and in two-drug combinations, using Yoshida sarcoma cells implanted into the wall of the glandular stomach of Sprague-Dawley rats. In monotherapy, the antibiotic agent mitomycin C and the nitrosourea methyl-CCNU exhibited the highest cytotoxic activity in this tumor model. In combination therapy, the combination of these two drugs was superior to all the other therapeutic schemes tested. In general, the results demonstrate a marked superiority of combination therapy in comparison with monotherapy.
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Banco de datos:
MEDLINE
Asunto principal:
Sarcoma de Yoshida
/
Neoplasias Gástricas
/
Antineoplásicos
Límite:
Animals
Idioma:
En
Año:
1983
Tipo del documento:
Article