Identification of monohydroxylated metabolites of cannabidiol formed by rat liver.
J Pharm Pharmacol
; 28(4): 275-9, 1976 Apr.
Article
en En
| MEDLINE
| ID: mdl-6714
ABSTRACT
Cannabidiol (CBD) was metabolized in vitro by rat liver enzymes. Unchanged CBD and eight monohydroxylated metabolites were isolated and positively identified. As previously reported, 7-hydroxy-CBD was the major metabolite. The second most abundant metabolite was 6alpha-hydroxy-CBD; whereas only a trace amount of 6beta-hydroxy-CBD was found. In addition hydroxylation occurred in all positions of the pentyl side chain, 4 inches-hydroxy-CBD being most abundant. 3 inches-Hydroxy-CBD was formed in half of the yield of 4 inches-hydroxy-CBD, while 1 inches-, 2 inches-, 5 inches-hydroxy-CBD were each formed in approximately one fourth of the yield of 4 inches-hydroxy-CBD.
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Banco de datos:
MEDLINE
Asunto principal:
Cannabidiol
/
Cannabis
/
Hígado
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Año:
1976
Tipo del documento:
Article