Primary sequence differences between Chido and Rodgers variants of tryptic C4d of the human complement system.
FEBS Lett
; 170(2): 254-8, 1984 May 21.
Article
en En
| MEDLINE
| ID: mdl-6723966
ABSTRACT
Human tryptic C4d of the Chido and Rodgers variant was fragmented by cyanogen bromide and trypsin. The fragments were characterized by amino acid analysis and sequence determination. Polymorphism between the two genetic variants was detected in 5 positions. Four were closely located (residues 141, 142, 145, 146), where Leu, Ser, Ile, His occurred in the Chido variant and Pro, Cys, Leu, Asp in the Rodgers variant, respectively. In position 94 Gly was found in Chido and Asp in Rodgers. Alignment of the fragments was performed and it is concluded that tryptic C4d of both variants contains 346 residues.
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Banco de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Variación Genética
/
Antígenos de Grupos Sanguíneos
/
Complemento C4
/
Complemento C4b
Límite:
Humans
Idioma:
En
Año:
1984
Tipo del documento:
Article