Comparative metabolism and carcinogenicity of ring-halogenated 3,3-dimethyl-1-phenyltriazenes.
J Cancer Res Clin Oncol
; 108(1): 71-5, 1984.
Article
en En
| MEDLINE
| ID: mdl-6746720
ABSTRACT
The objective of this study was to compare urinary metabolism of parent 3,3-dimethyl-1-phenyltriazene with that of its ring-substituted 1-(4-chlorophenyl)-3,3-dimethyltriazene and 1-(2,4,6-trichlorophenyl)-3,3-dimethyltriazene congeners, in an attempt to evaluate the molecular requirements for systemic carcinogenic activity. Complementary carcinogenicity assays were conducted at low equimolar dose levels using both 4- und 2,4,6-chlorinated and brominated analogues. Ring halogenation was found to prolong metabolic detoxification and to reduce carcinogenic activity.
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Banco de datos:
MEDLINE
Asunto principal:
Triazenos
/
Carcinógenos
/
Neoplasias Experimentales
Límite:
Animals
Idioma:
En
Año:
1984
Tipo del documento:
Article