N-alpha-formyl-tyrosyl-relaxin - a reliable tracer for relaxin radioimmunoassay.

ABSTRACT

Porcine relaxin has no radio-iodinatable amino acid and must therefore be modified prior to iodination. In this paper a synthesis of an iodinatable relaxin derivative is described which leads to a fairly uniform product. The nature of the modifying group (formyltyrosine) allows for easy and accurate estimation of the degree of substitution attained as well as determination of the position where substitution has occurred.