[Iproniazid-induced hepatitis. The diagnostic value of a new antimitochondrial antibody anti-M6]. / Hépatite à l'iproniazide. Intérêt diagnostique d'un nouvel anticorps antimitochondrial, l'anti-M6.
Gastroenterol Clin Biol
; 7(5): 529-32, 1983 May.
Article
en Fr
| MEDLINE
| ID: mdl-6873566
ABSTRACT
The authors report the observations of four patients with iproniazid hepatitis. Three of these patients died. An antimitochondrial antibody was found in the 4 patients at a high titer. This antibody differed from the antimitochondrial antibodies which have been described previously (anti-M1, anti-M5). This new antibody was called anti-M6. The evolution of the anti-M6 titer has been studied in the patient who survived. This titer progressively decreased; the antibody was no longer detectable 6 months after the withdrawal of iproniazid. Anti-M6 has not been found in other hepatic diseases. It was not detected in 15 patients receiving iproniazid without hepatitis or in 6 patients receiving isoniazid. Anti-M6 appears as a useful serologic marker for the diagnosis of iproniazid hepatitis.
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Banco de datos:
MEDLINE
Asunto principal:
Mitocondrias Hepáticas
/
Enfermedad Hepática Inducida por Sustancias y Drogas
/
Iproniazida
/
Anticuerpos
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Fr
Año:
1983
Tipo del documento:
Article