[Effect of ethymisole on long-term memory]. / O vliianii étimizola na dolgovremennuiu pamiat'.
Zh Vyssh Nerv Deiat Im I P Pavlova
; 28(4): 761-4, 1978.
Article
en Ru
| MEDLINE
| ID: mdl-695937
ABSTRACT
Influence of ethymisol (bismethylamid of 1-ethylimidasol-4,5-dicarbonic acid) on learning and retention of habit was studied in experiments on rats by the method of active conditioned avoidance of electrical stimulation. At the same time optimal conformation form of the drug was determined by the method of proton magnetic resonance and by means of infrared spectra and theoretical conformation analysis. A single administration of ethymisol in the dose of 3 mg/kg reduced the deficit of the avoidance habit, when tested in 30 and 60 days following learning. A stable conformation of the ethymisol molecule with a planar arrangement of atoms of its heterocycle and amide groups was found in which the interaction of this substance with biological macromolecules was most active. The ethymisol effect on the long-term memory apparently results from a stable facilitation of synaptic transmission based on stabilization of spatial structure of biological macromolecules in the given conformation.
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Banco de datos:
MEDLINE
Asunto principal:
Etimizol
/
Imidazoles
/
Memoria
Límite:
Animals
Idioma:
Ru
Año:
1978
Tipo del documento:
Article