Psoralen phototoxicity: correlation with serum and epidermal 8-methoxypsoralen and 5-methoxypsoralen in the guinea pig.
Science
; 217(4561): 733-5, 1982 Aug 20.
Article
en En
| MEDLINE
| ID: mdl-7100920
ABSTRACT
Serum and epidermal concentrations of 8-methoxypsoralen and 5-methoxypsoralen 2 hours after oral administration to guinea pigs were determined by high-performance liquid chromatography. A linear relation was found between the serum and epidermal concentrations of 8-methoxypsoralen. In addition, a relation was found between serum concentrations of 5-methoxypsoralen and 8-methoxypsoralen and the appearance of phototoxicity. The lower phototoxicity of orally administered 5-methoxypsoralen as compared to 8-methoxypsoralen in the guinea pig appears to be due to its reduced concentrations in the epidermis, the primary site of the phototoxic events.
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Banco de datos:
MEDLINE
Asunto principal:
Trastornos por Fotosensibilidad
/
Epidermis
/
Metoxaleno
Límite:
Animals
Idioma:
En
Año:
1982
Tipo del documento:
Article