Muscle glycolipids in inherited muscular dystrophy of chickens.
FEBS Lett
; 150(2): 359-64, 1982 Dec 27.
Article
en En
| MEDLINE
| ID: mdl-7160480
ABSTRACT
Gangliosides and neutral glycolipids of muscles from normal and dystrophic chickens were studied. Total glycolipid content of the degenerating muscles was higher than the normal muscles. In addition, the myopathic muscles contained a ganglioside which was absent in the unaffected muscles from normal and dystrophic chickens. Based on the thin-layer chromatographic mobility, treatment with neuraminidases from Vibrio cholerae and Arthrobacter ureafaciens, and reactivity of the asialo-derivative towards anti-ganglio-N-triaosylceramide antibody, the dystrophic-specific ganglioside was tentatively identified as GM2. Data obtained from young and old dystrophic chickens suggested a direct relationship of this ganglioside to muscular dystrophy.
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Banco de datos:
MEDLINE
Asunto principal:
Glucolípidos
/
Músculos
/
Distrofia Muscular Animal
Límite:
Animals
Idioma:
En
Año:
1982
Tipo del documento:
Article