An animal model for cicatrizing trachoma.
Invest Ophthalmol Vis Sci
; 21(3): 422-33, 1981 Sep.
Article
en En
| MEDLINE
| ID: mdl-7275529
ABSTRACT
An animal model of cicatrizing trachoma was developed in cynomolgus monkeys. This model is consistent with our hypothesis that repeated ocular inoculation of Chlamydia trachomatis, BOUR strain, mimics the repeated reinfection that occurs naturally in endemic human trachoma. A chronic follicular conjunctivitis developed, and scarring later appeared in the superior tarsal conjunctiva. The organism was reisolated after the infection and was also demonstrated cytologically. Specific antichlamydial antibodies of both the IgM and IgG types appeared in the sera of the monkeys. Histopathologic examination of conjunctiva showed a marked lymphocytic response and the presence of germinal centers; areas of conjunctival scar tissue were also examined. Efforts to produce a similar model in rhesus monkeys were less successful.
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Banco de datos:
MEDLINE
Asunto principal:
Tracoma
/
Cicatriz
/
Conjuntivitis
Límite:
Animals
Idioma:
En
Año:
1981
Tipo del documento:
Article