Rational use of antibiotic therapy after appendicectomy.
Br Med J
; 280(6210): 275-7, 1980 Feb 02.
Article
en En
| MEDLINE
| ID: mdl-7357339
ABSTRACT
A prospective randomised trial was carried out on 263 patients admitted for appendicectomy. In those patients with normal or inflamed appendix only, wound sepsis occurred in five (5%) of the 96 patients receiving metronidazole compared with seven (7%) of the 91 controls. In patients with gangrenous or perforated appendices, however, 15 of the 32 patients (47%) receiving ampicillin and five (16%) of 31 patients receiving metronidazole developed a wound infection (p less than 0.025). Therapeutic courses of metronidazole significantly reduced wound sepsis rate in those with gangrenous or perforated appendices. Together with another antibiotic it should form part of the management of such patients, but antibiotics are unlikely to reduce further the low rate of wound infection in patients with normal or inflamed appendices.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Apendicectomía
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Infección de la Herida Quirúrgica
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Ampicilina
/
Metronidazol
Tipo de estudio:
Clinical_trials
/
Observational_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Child
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Child, preschool
/
Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
1980
Tipo del documento:
Article