Synthesis and pharmacology of 8-amino-3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-cis-6,11-dimethyl-2,6-methano-3-benzazocine and related compounds.
J Med Chem
; 23(1): 71-4, 1980 Jan.
Article
en En
| MEDLINE
| ID: mdl-7359514
ABSTRACT
The little compound 1a has been prepared and was found to be a strong, orally active agonist with narcotic--antagonist properties. 1a was prepared by two independent routes (1) nitration of volazocine and subsequent reduction and (b) a sequence involving dissolving metal reduction of cyclazocine methyl ether, followed by oximination and Semmler--Wolff rearrangement. Several analogues were prepared and tested.
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Banco de datos:
MEDLINE
Asunto principal:
Ciclazocina
Límite:
Animals
Idioma:
En
Año:
1980
Tipo del documento:
Article