In vitro effects on DNA synthesis as a predictor of biological effect from chemotherapy.
Cancer Res
; 40(7): 2209-12, 1980 Jul.
Article
en En
| MEDLINE
| ID: mdl-7388789
ABSTRACT
Cell suspensions of tumor or normal bone marrow were incubated in vitro with control media (supplemented Ham's F-10 medium or autologous, pretreatment plasma) and with autologous, posttreatment plasma containing chemotherapeutic agents or their metabolites (treated plasma). Drug-specific perturbation of tumor cell DNA synthesis, as measured by the thymidine labeling index, occurred in treated plasma in 9 of 9 courses where antitumor effect was seen compared to 2 of 8 in which chemotherapy failed. Similar effects on myelocyte labeling index in normal marrow were observed in 14 of 20 courses associated with leukopenia and in 0 of 3 in which there was none. The labeling index was affected in 23 of 29 courses with associated biological effect (79%) versus 2 of 11 courses without biological effect (p = 0.0007). Measurement of changes in labeling index upon exposure to drug-containing plasma may become a useful guide to the choice of antineoplastic chemotherapy.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
ADN
/
ADN de Neoplasias
/
Neoplasias
/
Antineoplásicos
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Año:
1980
Tipo del documento:
Article