Interaction between acetylcholine and other agonists at cholinoreceptive membrane of mollusc neurons.
Brain Res
; 200(1): 190-4, 1980 Oct 27.
Article
en En
| MEDLINE
| ID: mdl-7417805
ABSTRACT
The effect of pretreatment with agonists of various chemical structure on acetylcholine action at isolated Limnaea stagnalis neurones was studied. Threshold concentrations of monoquaternary agonists or dicholinic ester of adipinic acid increase and inhibit the responses to low and high acetylcholine concentrations respectively. In contrast, suberyldicholine and compound IEM-1054 (containing two charged ammonium groups in a molecule with an internitrogen distance of 2.0-2.2 nm) decrease the action of any acetylcholine concentration. The results are discussed in terms of the cooperativity model of acetylcholine receptors (AChR) and the hypothesis about regular arrangement of AChRs in the membrane, the so called 'C-16 structure'.
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Banco de datos:
MEDLINE
Asunto principal:
Acetilcolina
/
Receptores Colinérgicos
/
Neuronas
Límite:
Animals
Idioma:
En
Año:
1980
Tipo del documento:
Article