A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors.
J Med Chem
; 38(23): 4679-86, 1995 Nov 10.
Article
en En
| MEDLINE
| ID: mdl-7473595
ABSTRACT
4-(Arylthio)-pyridin-2(1H)-ones variously substituted in their 3-, 5-, and 6-positions have been synthesized as a new series of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)-pyridinone hybrid molecules. Biological studies revealed that some of them show potent HIV-1 specific reverse transcriptase inhibitory properties. Compounds 16 and 7c, the most active ones, inhibit the replication of HIV-1 at 3 and 6 nM, respectively.
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Banco de datos:
MEDLINE
Asunto principal:
Antivirales
/
Piridonas
/
VIH-1
/
ADN Polimerasa Dirigida por ARN
/
Inhibidores de la Transcriptasa Inversa
Idioma:
En
Año:
1995
Tipo del documento:
Article