4-Guanidino-Neu5Ac2en fails to protect chickens from infection with highly pathogenic avian influenza virus.
Antiviral Res
; 27(1-2): 179-86, 1995 May.
Article
en En
| MEDLINE
| ID: mdl-7486955
ABSTRACT
The effectiveness of the novel sialidase inhibitor 4-guanidino-Neu5Ac2en, which is highly effective in mouse and ferret models of influenza virus infection (von Itzstein et al. (1993) Nature 363, 418-423), has been assessed as a prophylactic agent in the prevention of infection of chickens with highly pathogenic avian influenza viruses. At best a small delay in the onset of pyrexia and death was observed with one strain of fowl plague virus, but not with two other strains. These results demonstrate that a locally acting drug may be ineffective if virus can escape from the site of inoculation and replicate elsewhere.
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Banco de datos:
MEDLINE
Asunto principal:
Antivirales
/
Ácidos Siálicos
/
Pollos
/
Gripe Aviar
Límite:
Animals
Idioma:
En
Año:
1995
Tipo del documento:
Article