Apoptosis, Fas and systemic autoimmunity: the MRL-lpr/lpr model.
Curr Opin Immunol
; 6(6): 913-20, 1994 Dec.
Article
en En
| MEDLINE
| ID: mdl-7536012
ABSTRACT
Proteins encoded by the fas and fas ligand (fasL) genes are involved in apoptotic cell death in lymphocytes. In this article we review the recent elucidation of the role of the Fas-FasL interactions in the maintenance of tolerance to self antigens and in the homeostatic regulation of lymphocyte clonal expansion, and discuss the mechanisms of autoimmunity in Fas- and FasL-deficient mutant mouse strains.
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Banco de datos:
MEDLINE
Asunto principal:
Glicoproteínas de Membrana
/
Apoptosis
/
Trastornos Linfoproliferativos
/
Antígenos de Superficie
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Año:
1994
Tipo del documento:
Article