Divergence of insulin-like growth factors I and II in the elasmobranch, Squalus acanthias.
FEBS Lett
; 371(1): 69-72, 1995 Aug 28.
Article
en En
| MEDLINE
| ID: mdl-7545136
ABSTRACT
Recent studies have shown that vertebrates, including teleostean fishes, amphibians, birds and mammals, contain two distinct insulin-like growth factor (IGF) genes. In contrast agnathans, represented by hagfish, apparently have only one IGF that has features characteristic of both IGF-I and IGF-II. Between these groups the elasmobranchs occupy a critical position in terms of the phylogeny of IGFs. We sought to determine if gene duplication and divergence of IGF-I and IGF-II occurred before or after divergence of elasmobranchs from other vertebrates by cloning IGF-like molecules from Squalus acanthias. Our analysis shows that Squalus liver produces two distinct IGF-like molecules. One has greater sequence identity to, and conserved features characteristic of, known IGF-I molecules, while the other is more IGF-II like. These results suggest that the prototypical IGF molecule duplicated and diverged in an ancestor of the extant gnathostomes.
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Banco de datos:
MEDLINE
Asunto principal:
Filogenia
/
Factor I del Crecimiento Similar a la Insulina
/
Factor II del Crecimiento Similar a la Insulina
/
Cazón
/
Genes
Límite:
Animals
Idioma:
En
Año:
1995
Tipo del documento:
Article