Population differences in the frequency of the factor V Leiden variant among people with clinically symptomatic protein C deficiency.
J Med Genet
; 32(7): 543-5, 1995 Jul.
Article
en En
| MEDLINE
| ID: mdl-7562967
ABSTRACT
The factor V Leiden variant, responsible for the phenomenon of activated protein C resistance, was found to be less frequent among British (0.06) and Swedish/Danish (0.15) protein C deficiency patients than previously reported in a Dutch study (0.19). In the Swedish population, a significantly increased frequency of the factor V Leiden allele was apparent in protein C deficiency patients as compared to healthy controls. However, this was not found in the British population. Coinheritance of the factor V Leiden variant is therefore unlikely to be the sole determinant of whether a person with protein C deficiency will come to clinical attention. Nevertheless, when patient data were analysed by type of protein C deficiency, it was noted that the frequency of the factor V Leiden variant was 2.8-fold higher in type II patients compared to type I patients. A possible explanation of this disparity is discussed.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Trombosis
/
Factor V
/
Deficiencia de Proteína C
/
Deficiencia del Factor V
/
Frecuencia de los Genes
Tipo de estudio:
Diagnostic_studies
Límite:
Female
/
Humans
/
Male
País como asunto:
Europa
Idioma:
En
Año:
1995
Tipo del documento:
Article