The effect of systemic treatment with 5-fluorouracil on the epidermis of the guinea pig.
Arch Dermatol Res
; 263(1): 31-5, 1978.
Article
en En
| MEDLINE
| ID: mdl-757456
ABSTRACT
The thymidine labelling index and the mitosis rate (blocked by colcemid) in the basal cell layer of the guinea pig were determined before and during treatment with 5-fluorouracil (1 mg i.p. in 2 day's interval/100 g body weight). Additionally, the epidermal area and thickness and the number and size of cells were measured. 5-Fluorouracil equally reduces the thymidine labelling index and the mitosis rate with the full effect after treatment of at least 22 days. From these findings it is concluded that the S-phase--calculated from the end of the thymidine synthesis--is not altered. Furthermore atrophy of the epidermis runs parallel with the reduction of the 3H thymidine labelling index and the mitosis rate.
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Banco de datos:
MEDLINE
Asunto principal:
Epidermis
/
Fluorouracilo
Límite:
Animals
Idioma:
En
Año:
1978
Tipo del documento:
Article