Evidence of an X-linked or recessive genetic component to prostate cancer risk.
Nat Med
; 1(8): 827-9, 1995 Aug.
Article
en En
| MEDLINE
| ID: mdl-7585188
ABSTRACT
We used data from a population-based cohort study of blacks, Hispanics, Japanese and whites to examine the frequency of prevalent prostate and breast cancer by family history status of first-degree relatives (parents and siblings). Independent of race, the age-adjusted relative risk for prevalent prostate cancer in subjects with affected brothers was approximately two times that in subjects with affected fathers (P < 0.00005). No such excess risk for breast cancer was observed among subjects with affected sisters compared to those with affected mothers (age- and race-adjusted relative risk = 1.10, P = 0.34). The magnitude of the relative risk for prostate cancer in sibling- versus parent-affected groups was significantly different from that of the comparable relative risk for breast cancer (P < 0.00005). An excess risk of prostate cancer in men with affected brothers compared to those with affected fathers is consistent with the hypothesis of an X-linked, or recessive, model of inheritance.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Cromosoma X
/
Ligamiento Genético
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Female
/
Humans
/
Male
País como asunto:
America do norte
Idioma:
En
Año:
1995
Tipo del documento:
Article