Coronary artery response to cold-pressor test is impaired early after operation in heart transplant recipients.
J Am Coll Cardiol
; 26(2): 446-51, 1995 Aug.
Article
en En
| MEDLINE
| ID: mdl-7608449
ABSTRACT
OBJECTIVES:
The aim of the present study was to evaluate the coronary vasomotor response to the cold-pressor test within 3 months after heart transplantation.BACKGROUND:
Normal epicardial coronary arteries dilate in response to sympathetic stimulation evoked by the cold-pressor test. In transplant recipients, abnormal coronary vasomotion has been described shortly after operation.METHODS:
Fourteen heart transplant recipients were compared 52 +/- 15 days (mean +/- SD) after operation with 10 control subjects. All had angiographically normal epicardial coronary arteries. Coronary blood flow velocity was measured with a Doppler catheter placed in the proximal left anterior descending coronary artery. Four segments in each patient were analyzed by quantitative coronary angiography to assess the diameter changes during the cold-pressor test and after intracoronary injection of isosorbide dinitrate.RESULTS:
Coronary flow velocity increased similarly during the cold-pressor test in control subjects and in transplant recipients, from 7.5 +/- 2.3 to 11.0 +/- 3.9 cm/s and from 10.3 +/- 3.2 to 13.7 +/- 4.8 cm/s (both p < 0.01). In control subjects, 39 of 40 segments analyzed dilated during the cold-pressor test. In transplant recipients, 48 of 56 segments analyzed did not change or constricted. The mean epicardial coronary diameter increased significantly during the cold-pressor test in control subjects (+13 +/- 6%, p < 0.001), whereas it did not change significantly in transplant recipients (-2 +/- 9%, p = NS). In transplant recipients, isosorbide dinitrate elicited coronary vasodilation similar to that in control subjects.CONCLUSIONS:
These data indicate that in human transplanted denervated hearts, coronary vasodilation in response to sympathetic stimulation by cold exposure is impaired shortly after operation.
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Banco de datos:
MEDLINE
Asunto principal:
Trasplante de Corazón
/
Frío
/
Circulación Coronaria
/
Enfermedad Coronaria
/
Vasos Coronarios
Límite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Año:
1995
Tipo del documento:
Article