The gene for Bazex-Dupré-Christol syndrome maps to chromosome Xq.
J Invest Dermatol
; 105(1): 87-91, 1995 Jul.
Article
en En
| MEDLINE
| ID: mdl-7615983
ABSTRACT
Bazex-Dupré-Christol syndrome is an inherited condition with skin cancer predisposition characterized by follicular atrophoderma, hypotrichosis, and early onset of multiple basal cell carcinomas. Previous reports suggested an X-linked mode of inheritance. We therefore performed linkage analysis with microsatellite markers of the X chromosome in three families. We obtained evidence for X-linkage and regional assignment to Xq24-q27 of this syndrome (maximal lod score = 5.26 with a recombination fraction of 0% at the DXS1192 locus). This represents a first step towards the identification of a gene involved in hair follicle development and skin tumor formation.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
/
Cromosoma X
/
Carcinoma Basocelular
/
Mapeo Cromosómico
/
Hipotricosis
/
Ligamiento Genético
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Año:
1995
Tipo del documento:
Article