Interferon inducibility of mammalian tryptophanyl-tRNA synthetase: new perspectives.
Trends Biochem Sci
; 18(7): 263-7, 1993 Jul.
Article
en En
| MEDLINE
| ID: mdl-7692626
ABSTRACT
Mammalian aminoacyl-tRNA synthetases are indispensible components of the cell's protein-synthesizing machinery. Surprisingly, recent experiments have demonstrated that synthesis of tryptophanyl-tRNA synthetase (WRS) is markedly enhanced after incubation of human cells with interferons. Why is this housekeeping enzyme interferon-inducible? Several hypotheses have been suggested. One hypothesis, that premature termination of protein synthesis was involved, was boosted by the discovery that the deduced amino acid sequence of the mammalian peptide chain release factor (RF) closely resembled that of WRS. Further investigation, however, suggests that the DNA encoding RF was wrongly identified and in fact encodes a rabbit WRS subunit. Other hypotheses on the interferon-inducibility of WRS, including the possibility that the protein performs other, regulatory functions in addition to its core enzymic activity, remain to be explored.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Triptófano-ARNt Ligasa
/
Interferones
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Año:
1993
Tipo del documento:
Article