Constituents of Werneria ciliolata and their in vitro anti-HIV activity.
Phytochemistry
; 36(4): 991-6, 1994 Jul.
Article
en En
| MEDLINE
| ID: mdl-7765214
ABSTRACT
The aerial part of Werneria ciliolata afforded a series of new diterpenes two ent-kaurane derivatives, a norkaurane, an ent-manoyloxide derivative, a dimeric diterpene, as well as a rare diterpene. Their structures were elucidated by spectroscopic methods, including the concerted application of 1D NMR techniques (DEPT and NOEDS) and 2D NMR techniques (1H-1H COSY and HETCOR). In addition, four known kauranes, four coumarins and 6-hydroxytremetone were isolated. All isolated compounds from W. ciliolata and W. dactylophylla were tested in vitro for anti-viral activity against HIV-1, but only 6-hydroxytremetone showed a significant anti-HIV-1 activity.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Antivirales
/
Plantas
/
Extractos Vegetales
/
VIH-1
Idioma:
En
Año:
1994
Tipo del documento:
Article