The biosynthesis of the thiazole moiety of thiamine in Salmonella Typhimurium.
Biochim Biophys Acta
; 437(1): 229-37, 1976 Jun 23.
Article
en En
| MEDLINE
| ID: mdl-779848
ABSTRACT
The mechanism of biosynthesis of 4-methyl-5-beta-hydroxyethyl thiazole, the thiazole moiety of thiamine was studied in Salmonella typhimurium. Using the adenosine derepression technique the incorporation of various 14C-labeled precursors was determined. We found that;e1Me-14C]methionine, [2-14C]methionine, [U-14C]alanine, and [2-14C]glycine were not incorporated whereas [2-14C]tyrosine was incorporated. Degradation of the 4-methyl-5-beta-hydroxyethyl thiazole obtained after [2-14C]tyrosine incorporation revealed that all of the activity was located on carbon-2. These findings are discussed and compared with previous findings concerning 4-methyl-5-beta-hydroxyethyl thiazole biosynthesis.
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Banco de datos:
MEDLINE
Asunto principal:
Salmonella typhimurium
/
Tiamina
/
Tiazoles
Idioma:
En
Año:
1976
Tipo del documento:
Article