Human cortical neuronal (HCN) cell lines: a model for amyloid beta neurotoxicity.

Zhang, Z; Drzewiecki, G J; Hom, J T; May, P C; Hyslop, P A

Zhang, Z; Drzewiecki, G J; Hom, J T; May, P C; Hyslop, P A.

Zhang Z; Department of Central Nervous System Research, Lilly Research Laboratory, Lilly Corporate Center, Indianapolis, IN 46285.

Neurosci Lett ; 177(1-2): 162-4, 1994 Aug 15.

Article en En | MEDLINE | ID: mdl-7824173

ABSTRACT

ABSTRACT

Human cortical neuronal cell lines HCN-1A and HCN-2 are killed for following exposure of the differentiated cells to amyloid beta-peptide(1-40), a component of senile plaques and other amyloid deposits in brains from Alzheimer's patients. We present a model of A beta toxicity uncomplicated by the presence of other cell types that can be used to address the mechanism of A beta neurotoxicity. This model will be useful in the evaluation of neuroprotective compounds which may attenuate cortical neuronal loss in Alzheimer's disease.

Asunto(s)

Péptidos beta-Amiloides/toxicidad; Neuronas/efectos de los fármacos; Fragmentos de Péptidos/toxicidad; Biomarcadores; Muerte Celular; Línea Celular; Niño; Preescolar; Femenino; Humanos; Lactante

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Banco de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Péptidos beta-Amiloides / Neuronas Límite: Child / Child, preschool / Female / Humans / Infant Idioma: En Año: 1994 Tipo del documento: Article

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