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Effects of dietary supplementation with alpha-tocopherol on myocardial infarct size and ventricular arrhythmias in a dog model of ischemia-reperfusion.
Sebbag, L; Forrat, R; Canet, E; Renaud, S; Delaye, J; de Lorgeril, M.
  • Sebbag L; Institut National pour la Santé et la Recherche Medicale (INSERM), Unit 63, Lyon, France.
J Am Coll Cardiol ; 24(6): 1580-5, 1994 Nov 15.
Article en En | MEDLINE | ID: mdl-7930294
ABSTRACT

OBJECTIVES:

We investigated whether dietary supplementation with the antioxidant vitamin alpha-tocopherol (500 mg daily) might reduce lethal ventricular arrhythmias and infarct size.

BACKGROUND:

Previous studies suggested that dietary supplementation with alpha-tocopherol may be associated with a reduced risk of ischemic heart disease. However, the mechanism of this protection remains unknown.

METHODS:

Beagle dogs were randomized to either a supplemented or a control group. Because of the low mortality rate in the supplemented group, five dogs were added to the control group. After 2 months, dogs were anesthetized and underwent a 2-h coronary artery occlusion and 6-h reperfusion. Plasma vitamin E, retinol and malondialdehyde concentrations were assessed in all dogs.

RESULTS:

Fourteen dogs (11 of 25 control vs. 3 of 19 supplemented dogs, p < 0.05) developed ventricular fibrillation during either ischemia or reperfusion. Malondialdehyde concentrations were higher in dogs that subsequently developed arrhythmias (2.7 +/- 0.2 mumol/liter, mean +/- SEM) compared with dogs that did not (2.1 +/- 0.2 mumol/liter, p = 0.03). Among survivors with significant ischemia, infarct size was larger in supplemented (n = 12, 58.5 +/- 3.3% of area at risk) than in control (n = 11, 41.9 +/- 6.5%, p < 0.04) dogs. In addition, for a given collateral flow, supplemented dogs (n = 16) developed larger infarct size than control dogs (n = 15, p < 0.001, analysis of covariance).

CONCLUSIONS:

The data suggest that dietary alpha-tocopherol supplementation prevented lethal ventricular arrhythmias associated with ischemia and reperfusion. However, its influence on infarct size and long-term prognosis warrants further investigation.
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Banco de datos: MEDLINE Asunto principal: Arritmias Cardíacas / Vitamina E / Daño por Reperfusión Miocárdica / Alimentos Fortificados / Infarto del Miocardio Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Año: 1994 Tipo del documento: Article
Search on Google
Banco de datos: MEDLINE Asunto principal: Arritmias Cardíacas / Vitamina E / Daño por Reperfusión Miocárdica / Alimentos Fortificados / Infarto del Miocardio Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Año: 1994 Tipo del documento: Article