Inhibition of the growth of influenza viruses in vitro by 4-guanidino-2,4-dideoxy-N-acetylneuraminic acid.
Antiviral Res
; 24(4): 351-6, 1994 Aug.
Article
en En
| MEDLINE
| ID: mdl-7993078
ABSTRACT
The sialidase inhibitor 4-guanidino-2,4-dideoxy-2,3-dehydro-N- acetylneuraminic acid was tested for growth inhibitory effects against a panel of avian influenza A viruses encompassing all nine neuraminidase subtypes. Growth in tissue culture of viruses from each subtype was inhibited by this compound at concentrations within a range previously found effective against human N1 and N2 viruses. This compound may prove a selective agent for the treatment (and prevention) of influenza virus infections.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Antivirales
/
Virus de la Influenza A
/
Ácidos Siálicos
Idioma:
En
Año:
1994
Tipo del documento:
Article