Expression of the p53 gene in trophoblastic cells in hydatidiform moles and normal human placentas.
J Reprod Med
; 39(3): 223-7, 1994 Mar.
Article
en En
| MEDLINE
| ID: mdl-8035377
ABSTRACT
In this study we compared the expression of p53 in six early placentas and eight hydatidiform moles using Northern blotting. A higher expression of p53 in hydatidiform moles as compared to normal placentas of comparable gestational age was observed. Immunohistochemical studies did not detect mutant protein of p53 in the hydatidiform moles. DNA sequencing was performed on four of the hydatidiform moles with increased expression of p53, but no mutations could be detected. The possible role of p53 in the pathogenesis of hydatidiform mole is discussed.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Placenta
/
Neoplasias Uterinas
/
ADN de Neoplasias
/
Mola Hidatiforme
/
Regulación Neoplásica de la Expresión Génica
/
Genes p53
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Año:
1994
Tipo del documento:
Article