Chrymutasins: novel-aglycone antitumor antibiotics from a mutant of Streptomyces chartreusis. II. Characterization and structural elucidation.
J Antibiot (Tokyo)
; 47(6): 655-67, 1994 Jun.
Article
en En
| MEDLINE
| ID: mdl-8040070
ABSTRACT
Chrymutasins A, B and C are glycosidic antibiotics produced by a mutant of the chartreusin producer-organism Streptomyces chartreusis. We report here the structure elucidation of these compounds. The sugar moieties involved were determined by comparison with the related chartreusins. The structure of the aglycone, the same in all three compounds, was elucidated by NMR, incorporation studies of labeled compounds and synthesis of derivatives. The chrymutasin aglycone differs from that of chartreusin by a single carbon and an amino group.
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Banco de datos:
MEDLINE
Asunto principal:
Streptomyces
/
Antibióticos Antineoplásicos
Idioma:
En
Año:
1994
Tipo del documento:
Article