Richter's syndrome associated with loss of response to transforming growth factor-beta.

Nowell, P C; Moore, J S; Fox, F E; Capocasale, R J; Kant, J A; Besa, E C

Nowell, P C; Moore, J S; Fox, F E; Capocasale, R J; Kant, J A; Besa, E C.

Nowell PC; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-6082.

Leuk Res ; 18(2): 85-9, 1994 Feb.

Article en En | MEDLINE | ID: mdl-8107492

RESUMEN

A patient with chronic lymphocytic leukemia developed a large cell lymphoma apparently derived from the same neoplastic B-cell clone (Richter's syndrome). At the same time, mitogen-stimulated proliferation of the patient's circulating leukemic B-cells was no longer inhibited by the regulatory cytokine transforming growth factor-beta (TGF-beta), suggesting that such loss of inhibition might be contributing to the clinical and biological progression of the disease.

Asunto(s)

Linfocitos B/patología; Leucemia Linfocítica Crónica de Células B/patología; Linfoma de Células B/patología; Linfoma de Células B Grandes Difuso/patología; Factor de Crecimiento Transformador beta/farmacología; Anciano; División Celular; Depresión Química; Humanos; Masculino; Síndrome; Células Tumorales Cultivadas/patología

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Banco de datos: MEDLINE Asunto principal: Linfocitos B / Leucemia Linfocítica Crónica de Células B / Linfoma de Células B / Factor de Crecimiento Transformador beta / Linfoma de Células B Grandes Difuso Tipo de estudio: Risk_factors_studies Límite: Aged / Humans / Male Idioma: En Año: 1994 Tipo del documento: Article

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