Hepatocarcinoma-specific mutant p53-249ser induces mitotic activity but has no effect on transforming growth factor beta 1-mediated apoptosis.
Cancer Res
; 54(8): 2064-8, 1994 Apr 15.
Article
en En
| MEDLINE
| ID: mdl-8174105
ABSTRACT
Mutations affecting the p53 gene abrogate its tumor suppressor activity. It is, however, unclear whether such mutations can generate mutant p53 proteins with an intrinsic transforming ability. More importantly, the mechanism(s) by which they exert such activity is unknown. We report here that p53-deficient hepatoma cells (Hep3B) transfected with mutant p53-249ser (codon 249 Arg-->Ser) acquire a new phenotype with an increased in vitro survival and mitotic activity. However, such a phenotypic change is not sufficient to cause a major shift in the poor tumorigenic potential of these cells. This is apparently due to transforming growth factor beta 1-mediated apoptotic death of Hep3B cells which is not affected by the expression of p53-249ser.
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Banco de datos:
MEDLINE
Asunto principal:
Genes p53
/
Factor de Crecimiento Transformador beta
/
Mutación Puntual
/
Apoptosis
/
Carcinoma Hepatocelular
/
Neoplasias Hepáticas
/
Mitosis
Límite:
Animals
/
Humans
Idioma:
En
Año:
1994
Tipo del documento:
Article