Translocation of Thorotrast in the body.
Radiat Res
; 138(3): 409-14, 1994 Jun.
Article
en En
| MEDLINE
| ID: mdl-8184016
ABSTRACT
To investigate whether there is a permanent translocation of Thorotrast in the body, the liver of male Lewis rats was removed 4 weeks after injection of Thorotrast (300 microliters) and replaced by a donor liver. In half of the animals the spleen was removed as well. Measuring the 232Th content in the donor liver at different times after implantation demonstrated a permanent transport of 232Th into the surrogate organ. After 231 days a 232Th depot of about 1.1 mg was found, representing about 3% of the total body burden. The additional removal of the spleen resulted in a significantly lower transport of 232Th into the implanted liver. Histological examinations of the donated livers revealed increasing local concentration of Thorotrast granules, leading to the development of conglomerates. A comparable translocation of Thorotrast was verified in two humans who required liver transplantation more than 40 years after Thorotrast injection.
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Banco de datos:
MEDLINE
Asunto principal:
Dióxido de Torio
/
Hígado
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Año:
1994
Tipo del documento:
Article