The suitability of carboplatin solutions for 14-day continuous infusion by ambulatory pump: an HPLC-dynamic FAB study.

Hadfield, J A; McGown, A T; Dawson, M J; Thatcher, N; Fox, B W

Hadfield, J A; McGown, A T; Dawson, M J; Thatcher, N; Fox, B W.

Hadfield JA; CRC Department of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.

J Pharm Biomed Anal ; 11(8): 723-7, 1993 Aug.

Article en En | MEDLINE | ID: mdl-8257737

RESUMEN

The stability of aqueous carboplatin solutions over 14 days has been studied at 37 and 60 degrees C. High-performance liquid chromatography and dynamic FAB mass spectrometry studies have shown that carboplatin solutions were stable at 37 degrees C but degraded at 60 degrees C. Fluid loss through evaporation was significant at the higher temperature.

Asunto(s)

Carboplatino/química; Estabilidad de Medicamentos; Carboplatino/administración & dosificación; Cromatografía Líquida de Alta Presión; Bombas de Infusión; Infusiones Intravenosas; Espectrometría de Masa Bombardeada por Átomos Veloces; Temperatura

Search on Google

Imprimir

XML

PubMed Links

Banco de datos: MEDLINE Asunto principal: Carboplatino / Estabilidad de Medicamentos Idioma: En Año: 1993 Tipo del documento: Article

Search on Google

Imprimir

XML

PubMed Links

Banco de datos: MEDLINE Asunto principal: Carboplatino / Estabilidad de Medicamentos Idioma: En Año: 1993 Tipo del documento: Article