Prostaglandin E2 antagonizes gingival fibroblast proliferation stimulated by interleukin-1 beta.
Prostaglandins Leukot Essent Fatty Acids
; 49(5): 847-50, 1993 Nov.
Article
en En
| MEDLINE
| ID: mdl-8302918
ABSTRACT
Treatment of human gingival fibroblasts with prostaglandin E2 (PGE2) resulted in significant concentration-dependent inhibition in deoxyribonucleic acid (DNA) synthesis (8.40-37.89%), while indomethacin (INDO) (PG inhibitor), interleukin-1 beta (IL-1 beta) or IL-1 beta+INDO caused a significant and dose-dependent increase in DNA synthesis. Addition of PGE2 to culture media containing IL-1 beta and INDO caused a significant concentration-dependent reduction in IL-1 beta- and INDO-induced stimulation of DNA synthesis. The findings suggest that IL-1 beta and PGE2, which are also produced by fibroblasts, could play an important role in regulation of gingival tissue development and wound healing, and their modulation may have therapeutic potential.
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Banco de datos:
MEDLINE
Asunto principal:
Dinoprostona
/
Interleucina-1
/
Fibroblastos
/
Encía
Límite:
Adult
/
Humans
Idioma:
En
Año:
1993
Tipo del documento:
Article