Cadmium-induced hepatotoxicity in three different rat strains.
Toxicol Lett
; 70(1): 39-48, 1994 Jan.
Article
en En
| MEDLINE
| ID: mdl-8310455
ABSTRACT
Cadmium (Cd) is a highly toxic element able to induce acute liver injury in rats after intraperitoneal administration. The dose-dependent Cd-induced hepatotoxicity was examined in three different rat strains. A difference in hepatotoxicity was observed in the three rat strains, determined by the examination of serum enzymes' activities and other biochemical parameters, all markedly altered after Cd intoxication. The histological findings came to confirm the variations of the above-mentioned parameters. It is concluded that the administration of this toxic agent caused different toxicity in the three rat strains examined, indicating a more intense damage in Wistar than in Quinster and Lewis rats.
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Banco de datos:
MEDLINE
Asunto principal:
Cadmio
/
Hígado
Límite:
Animals
Idioma:
En
Año:
1994
Tipo del documento:
Article