A randomized double-blind study of fluoxetine versus placebo in the treatment of dysthymia.
Am J Psychiatry
; 150(8): 1169-75, 1993 Aug.
Article
en En
| MEDLINE
| ID: mdl-8328559
ABSTRACT
OBJECTIVE:
The purpose of this study was to assess the efficacy of fluoxetine, a selective serotonergic antidepressant, in the treatment of dysthymia.METHOD:
Thirty-five patients who met criteria for dysthymia, but not major depression, began randomized, double-blind 8-week trials of fluoxetine or placebo.RESULTS:
Of 32 patients who completed the study, 10 (62.5%) of the 16 patients given fluoxetine and three (18.8%) of the 16 given placebo responded to treatment. Response was defined as 1) 50% or greater decrease in Hamilton Rating Scale for Depression score and 2) a score of 1 or 2 on the Clinical Global Impression (CGI) improvement subscale. Fluoxetine subjects showed significantly greater improvement at week 8 than placebo subjects on the Hamilton depression and CGI scales, but not on the Hopkins Symptom Check-list (58-item) or the Cornell Dysthymia Rating Scale.CONCLUSIONS:
When compared to placebo, fluoxetine showed short-term effectiveness in treating dysthymic symptoms.
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Banco de datos:
MEDLINE
Asunto principal:
Fluoxetina
/
Trastorno Depresivo
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Año:
1993
Tipo del documento:
Article