Clinical implications of tumor volume measurement in stage I adenocarcinoma of the cervix.
Obstet Gynecol
; 81(2): 296-300, 1993 Feb.
Article
en En
| MEDLINE
| ID: mdl-8423968
ABSTRACT
OBJECTIVE:
To evaluate the prognostic significance of three-dimensional determination of tumor size in stage I cervical adenocarcinoma.METHODS:
Tumor volume was measured using hematoxylin and eosin-stained sections of cone biopsy and hysterectomy specimens from 36 patients with stage I adenocarcinoma of the cervix. The volume was then correlated with pelvic lymphatic spread and clinical outcome.RESULTS:
The subjects were followed for a mean (+/- SEM) of 63 +/- 8 months. No recurrence or lymphatic seeding was encountered in the 22 tumors measuring no more than 500 mm3. Two of 25 tumors (8%) having up to 5 mm depth of stromal invasion had lymph node metastasis, one of which was 1.5 mm, compared with four of 11 (36%) in the group with deeper than 5 mm invasion (P < .02). The depth of stromal invasion predicted recurrence less significantly. Among the 25 tumors with up to 5 mm stromal invasion, two recurred, compared with three of 11 with more than 5 mm invasion (P < .1). Two women who had tumor volumes below 500 mm3 and depths of stromal invasion up to 8.5 mm were disease-free at 52 and 96 months of follow-up. On the other hand, tumors with 2.6 and 3.8 mm stromal invasion, but with volumes exceeding 500 mm3, recurred.CONCLUSION:
Tumor volume is a better predictor of pelvic lymph node metastasis and recurrence than is the depth of stromal invasion in stage I cervical adenocarcinoma.
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Banco de datos:
MEDLINE
Asunto principal:
Adenocarcinoma
/
Neoplasias del Cuello Uterino
/
Cuello del Útero
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Año:
1993
Tipo del documento:
Article