Linkage study of the D5 dopamine receptor gene (DRD5) in multiplex Icelandic and English schizophrenia pedigrees.
Am J Psychiatry
; 153(1): 107-9, 1996 Jan.
Article
en En
| MEDLINE
| ID: mdl-8540565
ABSTRACT
OBJECTIVE:
The authors investigated the possibility that genetic variation or mutation of the dopamine D5 receptor gene might modify susceptibility to schizophrenia.METHOD:
Twenty-three Icelandic and English pedigrees containing multiple cases of schizophrenia were genotyped by using a highly informative microsatellite for the D5 dopamine receptor gene DRD5.RESULTS:
By means of three different affection models, negative lod scores were obtained under assumptions of autosomal dominant and recessive inheritance. There was no evidence for locus heterogeneity. Nonparametric extended relative pair analysis also produced negative results.CONCLUSIONS:
These data indicate that mutations of the D5 dopamine receptor gene are not a major cause of schizophrenia in these pedigrees. Because of the probable existence of locus heterogeneity, the D5 receptor gene may be of etiologic importance in other families with schizophrenia.
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Banco de datos:
MEDLINE
Asunto principal:
Esquizofrenia
/
Receptores de Dopamina D1
Tipo de estudio:
Prognostic_studies
Límite:
Humans
País como asunto:
Europa
Idioma:
En
Año:
1996
Tipo del documento:
Article