AH17, a new non-polyenic antifungal antibiotic produced by a strain of Spirillospora.

ABSTRACT

An antibiotic (AH17) was produced by Spirillospora strain 719. This substance was obtained only from the broth filtrate after precipitation with acetic acid followed by extraction with n-butanol. Its purification was carried out by thin layer chromatography on silica gel followed by HPLC procedures. It showed activity against Gram-positive and Gram-negative bacteria and fungi. The spectroscopic and chemical properties were examined and indicated that AH17 was a quinone. It seems that this is a new antibiotic from Spirillospora.