Nonpeptidic HIV protease inhibitors: 4-hydroxy-pyran-2-one inhibitors with functional tethers to P1 phenyl ring to reach S3 pocket of the enzyme.

Vara Prasad, J; Tummino, P J; Ferguson, D; Saunders, J; Vander Roest, S; McQuade, T J; Heldsinger, A; Reyner, E L; Stewart, B H; Guttendorf, R J; Para, K S; Lunney, E A; Gracheck, S J; Domagala, J M

Vara Prasad, J; Tummino, P J; Ferguson, D; Saunders, J; Vander Roest, S; McQuade, T J; Heldsinger, A; Reyner, E L; Stewart, B H; Guttendorf, R J; Para, K S; Lunney, E A; Gracheck, S J; Domagala, J M.

Vara Prasad J; Department of Chemistry, Division of Warner-Lambert Company, Ann Arbor, Michigan 48106, USA.

Biochem Biophys Res Commun ; 221(3): 815-20, 1996 Apr 25.

Article en En | MEDLINE | ID: mdl-8630044

Asunto(s)

Inhibidores de la Proteasa del VIH/química; Pironas/química; Línea Celular; VIH-1/enzimología; Humanos; Estructura Molecular

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Banco de datos: MEDLINE Asunto principal: Pironas / Inhibidores de la Proteasa del VIH Límite: Humans Idioma: En Año: 1996 Tipo del documento: Article

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Imprimir

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PubMed Links

Banco de datos: MEDLINE Asunto principal: Pironas / Inhibidores de la Proteasa del VIH Límite: Humans Idioma: En Año: 1996 Tipo del documento: Article