Gestational choriocarcinoma of the ovary diagnosed by analysis of tumour DNA.
Cancer Lett
; 104(1): 27-30, 1996 Jun 24.
Article
en En
| MEDLINE
| ID: mdl-8640741
ABSTRACT
Gestational choriocarcinoma of the ovary is a rare form of malignancy which can be difficult to distinguish from primary ovarian choriocarcinoma. The ability to make such a diagnosis could, however, have important implications for therapy. We report here a case of choriocarcinoma whose origins were difficult to determine and which behaved clinically more like a primary rather than a gestational choriocarcinoma. We have analysed DNA from this tumour by using polymerase chain reaction (PCR) amplification of a range of polymorphic alleles and have demonstrated that the tumour was in fact gestational. Furthermore, the lack of chromosome Y sequences and the presence of heterozygosity of the spouse's alleles, indicated that this tumour arose as a result of dispermic fertilisation of an empty ovum by sperm carrying the X chromosome.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Ováricas
/
ADN de Neoplasias
/
Coriocarcinoma
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
Idioma:
En
Año:
1996
Tipo del documento:
Article