The roles of trp and calcium in regulating photoreceptor function in Drosophila.
Curr Opin Neurobiol
; 6(4): 459-66, 1996 Aug.
Article
en En
| MEDLINE
| ID: mdl-8794093
ABSTRACT
Invertebrate photoreceptors use the ubiquitous inositol-lipid signaling pathway for phototransduction. This pathway depends on Ca2+ release from internal stores and on Ca2+ entry via light-activated channels to replenish the loss of Ca2+ in those stores. The Drosophila transient receptor potential (TRP) protein is essential for the high Ca2+ permeability and other biophysical properties of these light-activated channels, which affect both excitation and adaptation in photoreceptor cells. Physiological and heterologous expression studies indicate that TRP is a putative subunit of a surface membrane channel that can be activated by depletion of internal Ca2+ stores. Furthermore, trp is an archetypal member of a multigene family whose products share a structure that is highly conserved throughout evolution, from worms to humans.
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Banco de datos:
MEDLINE
Asunto principal:
Canales de Calcio
/
Calcio
/
Células Fotorreceptoras de Invertebrados
/
Drosophila
/
Canales Iónicos
Límite:
Animals
Idioma:
En
Año:
1996
Tipo del documento:
Article