The effectiveness of barrier methods of contraception in preventing the spread of HIV.
AIDS
; 9 Suppl A: S85-93, 1995.
Article
en En
| MEDLINE
| ID: mdl-8819574
ABSTRACT
PIP: The effectiveness of barrier methods of contraception in preventing sexually transmitted diseases (STDs) such as human immunodeficiency virus (HIV) has been assessed in vitro studies and epidemiologic research. Both types of studies have indicated that consistent use of high-quality latex condoms confers substantial protection against HIV transmission. Less certain is the capability of nonoxynol-9 to inactivate HIV. Of concern are several studies indicating that 1-8% of female nonoxynol-9 users experience signs and symptoms of tissue irritation, which can facilitate HIV transmission. These findings may reflect overenrollment of women with a high incidence of STDs and above-average (more than one per day) spermicide doses. Meetings sponsored by the World Health Organization and the US Public Health Service during 1993-94 reached consensus on five ethical and methodological principles to govern studies investigating whether currently available nonoxynol-9 spermicides reduce the incidence of HIV infections: 1) a randomly allocated controlled trial in which all participants are given male condoms; 2) allocation of half the women to an active spermicidal product and the other half to a placebo product; 3) counseling participants to use both a condom and the vaginal product at every coital act; 4) sufficient study size to measure HIV rate ratios within frequency strata; and 5) inclusion of colposcopic examinations and regular appraisal of participant safety by a data and safety monitoring board. Studies of less irritating yet effective spermicidal compounds, the determinants of consistent use of barrier methods, and the impact of social marketing are also recommended.
Palabras clave
Acquired Immunodeficiency Syndrome--prevention and control; Barrier Methods; Clinical Research; Condom; Contraception; Contraceptive Agents; Contraceptive Methods; Diseases; Family Planning; Hiv Infections--prevention and control; Infections; Literature Review; Nonoxynol-9; Reproductive Tract Infections; Research Methodology; Sexually Transmitted Diseases--prevention and control; Spermicidal Contraceptive Agents; Viral Diseases
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Banco de datos:
MEDLINE
Asunto principal:
Infecciones por VIH
/
Anticoncepción
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Límite:
Humans
/
Male
Idioma:
En
Año:
1995
Tipo del documento:
Article