Vasodilator effect of human adrenomedullin(13-52) on hypertensive rats.

Tian, Q; Zhao, D; Tan, D Y; Zhao, Y T; Li, Q H; Qiu, J X; Song, L W; Gong, C N; Yang, J; Lippton, H

Tian, Q; Zhao, D; Tan, D Y; Zhao, Y T; Li, Q H; Qiu, J X; Song, L W; Gong, C N; Yang, J; Lippton, H.

Tian Q; J.K. Chang Peptide Research Laboratory, Beijing Medical University, People's Republic of China.

Can J Physiol Pharmacol ; 73(7): 1065-9, 1995 Jul.

Article en En | MEDLINE | ID: mdl-8846402

ABSTRACT

ABSTRACT

Human adrenomedullin (hADM) is a newly isolated peptide with hypotensive activity in normotensive rats. The objective of this study was to investigate the effect of hADM(13-52) on hypertensive animals. hADM(13-52) induced a dose-dependent decrease in the blood pressure of spontaneously hypertensive rats and renal hypertensive rats. This result suggests that hADM is a novel antihypertensive peptide. In isolated rat aortic arteries, hADM(13-52) produced nitric oxide dependent relaxation and inhibited endothelin 1 and angiotensin II release. These in vitro effects may represent the molecular mechanisms underlying the hypotensive action of hADM in vivo.

Asunto(s)

Antihipertensivos/farmacología; Hipertensión/fisiopatología; Fragmentos de Péptidos/farmacología; Vasodilatadores/farmacología; Adrenomedulina; Angiotensina II/metabolismo; Animales; Presión Sanguínea/efectos de los fármacos; Endotelinas/metabolismo; Humanos; Técnicas In Vitro; Masculino; Óxido Nítrico/fisiología; Ratas; Ratas Endogámicas SHR; Ratas Endogámicas WKY; Ratas Wistar

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Banco de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Vasodilatadores / Hipertensión / Antihipertensivos Límite: Animals / Humans / Male Idioma: En Año: 1995 Tipo del documento: Article

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