Failure of Nd-YAG photocoagulation therapy as treatment for Barrett's oesophagus--a pilot study.
Eur J Gastroenterol Hepatol
; 8(7): 627-30, 1996 Jul.
Article
en En
| MEDLINE
| ID: mdl-8853248
ABSTRACT
INTRODUCTION:
Acid suppression therapy and surgical antireflux procedures have not consistently led to regression of Barrett's epithelium. We reasoned that laser photocoagulation in combination with powerful acid suppression might destroy the metaplastic columnar epithelium and allow the area to be replaced by normal squamous mucosa. PATIENTS ANDMETHODS:
Eight patients with endoscopic and histologically proven Barrett's oesophagus were recruited into the study. Four patients were randomized to receive omeprazole 40 mg daily and four patients received the same medical therapy plus repeated laser photocoagulation administered at 4-6 weekly intervals. Endoscopies were performed on entry and at 6 months. The extent of Barrett's epithelium was assessed and mapped on to a grid system and histological changes were assessed in blinded manner by a single histopathologist. One new quadrant of Barrett's segment was irradiated per treatment.RESULTS:
Laser therapy was well tolerated and no complications occurred. After 6 months, the extent of Barrett's epithelium was unchanged in both groups. There was no appearance of squamous islands either endoscopically or microscopically in areas treated with laser.CONCLUSION:
Nd-YAG laser is ineffective in ablating Barrett's epithelium.
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Banco de datos:
MEDLINE
Asunto principal:
Esófago de Barrett
/
Coagulación con Láser
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
1996
Tipo del documento:
Article