A quantitative population model of whisker barrels: re-examining the Wilson-Cowan equations.
J Comput Neurosci
; 3(3): 247-64, 1996 Sep.
Article
en En
| MEDLINE
| ID: mdl-8872703
ABSTRACT
Beginning from a biologically based integrate and fire model of a rat whisker barrel, we employ semirigorous techniques to reduce the system to a simple set of equations, similar to the Wilson-Cowan equations, while retaining the ability for both qualitative and quantitative comparisons with the biological system. This is made possible through the clarification of three distinct measures of population activity voltage, firing rate, and a new term called synaptic drive. The model is activated by prerecorded neural activity obtained from thalamic "barreloid" neurons in response to whisker stimuli. Output is produced in the form of population PSTHs, one each corresponding to activity of spiny (excitatory) and smooth (inhibitory) barrel neurons, which is quantitatively comparable to PSTHs from electrophysiologically studied regular-spike and fast-spike neurons. Through further analysis, the model yields novel physiological predictions not readily apparent from the full model or from experimental studies.
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Banco de datos:
MEDLINE
Asunto principal:
Corteza Somatosensorial
/
Vibrisas
/
Redes Neurales de la Computación
Tipo de estudio:
Prognostic_studies
/
Qualitative_research
Límite:
Animals
Idioma:
En
Año:
1996
Tipo del documento:
Article